TSPY, the Candidate Gonadoblastoma Gene on the Human Y Chromosome, has a Widely Expressed Homologue on the X - Implications for Y Chromosome Evolution |
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Authors: | Margaret L. Delbridge Guy Longepied Danielle Depetris Marie-Genevieve Mattei Christine M. Disteche Jennifer A. Marshall Graves Michael J. Mitchell |
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Affiliation: | INSERM U.491 Faculté de Médecine, 27 bd Jean Moulin, 13385 Marseille Cedex 05, France. delbridge@rsbs.anu.edu.au |
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Abstract: | TSPY, a candidate gene for a factor that promotes gonadoblastoma formation (GBY), is a testis-specific multicopy gene family in the male-specific region of the human Y (MSY) chromosome. Although it was originally proposed that male-specific genes on the Y originated from a transposed copy of an autosomal gene (Lahn & Page 1999b), at least two male-specific genes (RBMY and SRY) descended from a formerly recombining X-Y identical gene pair. Here we show that a TSPY homologue with similar gene structure lies in conserved positions, close to SMCX, on the X chromosome in human (TSPX ) and mouse (Tspx). TSPX is widely expressed and subject to X inactivation. TSPX and TSPY therefore evolved from an identical gene pair on the original mammalian sex chromosomes. This supports the hypothesis that even male-specific genes on the Y chromosome may have their origin in ubiquitously expressed genes on the X. It also strengthens the case for TSPY as a candidate for GBY, since independent functional studies link TSPX to cell cycle regulation. |
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Keywords: | evolution TSPY X chromosome Y chromosome |
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