HIV病发病学新概念：肠淋巴组织主要病灶论

艾滋病 (acquiredimmunodeficiencysyndrome ,AIDS)无疑是人类空前严重的疾病 ,这不仅仅因为它是一种流行范围最广的传染病 ,而且它还是一种死亡率几乎高达 10 0 %的疾病。人免疫缺陷病毒病(humanimmunodeficiencyvirusdisease ,HIVdisease)指从HIV感染到AIDS发病整个病程 ,HIV

New concepts in pathogenesis of HIV disease: hypothesis main pathogenic site of intestinal lymphoid tissue

Given its population of CCR5-expressing, immunologically activated CD4 T cells, the gastrointestinal (GI) mucosa is uniquely susceptible to human immunodeficiency virus (HIV)-1 infection. Recent studies have shown that, as in macaques infected with simian immunodeficiency virus (SIV), intestinal CD4 T cells are selectively and rapidly depleted in the intestine of HIV-infected patients. Depletion of intestinal CD4 T cells occurred at all stages of infection regardless of highly active antiretroviral therapy (HAART). Here we discuss the important implications of the recent findings for our understanding of HIV pathogenesis, treatment, and vaccine design. The major significance is that it supports a simple hypothesis to explain the pathogenesis of HIV infection, that most HIV replication occurs in the intestine and that disease progression may correlate with turnover of specific cell subsets in mucosal tissues.