贲门癌组织P53、P21和CD44V6蛋白的表达及其意义

目的探讨P53、P21和CD44v6蛋白的表达情况与贲门癌生物学行为的关系.方法采用免疫组化法对41例贲门癌组织进行P53、P21和CD44V6蛋白的测定.结果贲门癌组织中P53、P21和CD44V6蛋白的阳性率分别为75.6%、53.6%和41.4%,其表达与患者性别、年龄、临床分期和病理类型无明显关系.CD44V6蛋白阳性表达与肿瘤浸润深度有关(P＜0.05);P53蛋白表达与P21蛋白表达呈正相关,但无统计学意义.P53、P21和CD44v6蛋白阳性者预后比其阴性者差.结论P53、P21和CD44v6蛋白的测定可作为判断贲门癌患者预后的参考指标,可能还存在其它影响预后的因素.

Expression and significance of P53、P21and CD44V6 protein in gastric cardiac carcinoma

Objective To study the correlation of the expression of P 53 ?P 21 and CD 44V6 protein with biological behaviors in gastric cardiac carcinoma.Methods The expressions of P 53 ?P 21 and CD 44V6 protein were determined by immunohistochemical method in 41 cases of gastric cardiac carcinoma.Results The positive rates of P 53 ?P 21 and CD 44V6 protein were 75.6%.53.6% and 41.4% respectively.There were no significant correlation between the expression of P 53 ?P 21 and CD 44V6 protein and sex.age,clinical stages and histopathological types of patients.The expression of CD 44V6 protein showed significant correlation with the depth of tumor invation ( P <0 05).The expression of P 53 was positively correlated with that of P 21 ( P >0 05).The prognosis with positive expression of P 53 ?P 21 and CD 44V6 protein was bad than that negative expression.Conclusion The expression of P 53 ?P 21 and CD 44V6 protein might be useful for evaluating the prognosis of gastric cardiac carcinoma.