NADH dehydrogenase in cystic fibrosis |
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| Authors: | Nelson R. Sanguinetti-Briceno David J. H. Brock |
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| Affiliation: | Department of Human Genetics, University of Edinburgh, Western General Hospital, Edinburgh, Scotland |
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| Abstract: | It has been claimed that the pH profile of mitochondrial NADH dehydrogenase in cultured skin fibroblasts can be used to distinguish cystic fibrosis homozygotes, heterozygotes and normal controls. This phenomenon has been examined in more readily accessible white blood cell preparations. The relative changes of activity of white cell NADH dehydrogenase in phosphate buffer at pH 8.0,8.3 and 8.6 were too small and too random to be useful in identifying the genotype of the donor. |
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| Keywords: | Cultured fibroblasts cystic fibrosis mitochondrial NADH dehydrogenase white blood cells |
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