| 微核试验方法的研究进展 |
| |
| 引用本文： | 曲见松,袁敬清,赵艳霞,范治云,祝清芬. 微核试验方法的研究进展[J]. 药学研究, 2017, 36(10): 602-604. DOI: 10.13506/j.cnki.jpr.2017.10.012 |
| |
| 作者姓名： | 曲见松 袁敬清 赵艳霞 范治云 祝清芬 |
| |
| 作者单位： | 1. 山东省食品药品检验研究院,山东 济南,250101;2. 山东亨利医药科技有限责任公司,山东 济南,250102 |
| |
| 摘 要： | 微核试验作为遗传毒性的检测方法,广泛应用于药品、化妆品、保健食品等领域的毒性评价,能够灵敏地反映出遗传毒性物质对染色体的损伤.随着检测技术的进步和新方法的应用,对于微核的检测手段也越来越多样.本文着重阐述了目前微核检测的技术方法,以期对现有的微核检测技术的应用提供参考依据.
|
| 关 键 词： | 微核试验 遗传毒性 流式细胞术 |
Research progress of the methods of micronucleus assay |
| |
| QU Jiansong,YUAN Jingqing,ZHAO Yanxi,FAN Zhiyun and ZHU Qingfen. Research progress of the methods of micronucleus assay[J]. Journal of Pharmaceutical Research, 2017, 36(10): 602-604. DOI: 10.13506/j.cnki.jpr.2017.10.012 |
| |
| Authors: | QU Jiansong YUAN Jingqing ZHAO Yanxi FAN Zhiyun ZHU Qingfen |
| |
| Affiliation: | 1.Shandong Insititute for Food and Drug Control,Jinan 250101,China; 2.KBP BioSciences Co.,Ltd.,Jinan 250102,China,1.Shandong Insititute for Food and Drug Control,Jinan 250101,China; 2.KBP BioSciences Co.,Ltd.,Jinan 250102,China,1.Shandong Insititute for Food and Drug Control,Jinan 250101,China; 2.KBP BioSciences Co.,Ltd.,Jinan 250102,China,1.Shandong Insititute for Food and Drug Control,Jinan 250101,China; 2.KBP BioSciences Co.,Ltd.,Jinan 250102,China and 1.Shandong Insititute for Food and Drug Control,Jinan 250101,China; 2.KBP BioSciences Co.,Ltd.,Jinan 250102,China |
| |
| Abstract: | Micronucleus (MN) assay as an examination for genetic toxicity evaluation has been widely used in drugs,cosmetics,health food and other fields.The assay could sensitively reflect the damage of genetic toxicity to the chromosome.With the development of detection technology and the application of new methods,the detection methods of micronucleus were more and more diverse.This review focused on the current technology of micronucleus detection, and provided references for the application of micronucleus detection technology. |
| |
| Keywords: | Micronucleus assay Genetic toxicity Flow cytometric |
| 本文献已被 万方数据 等数据库收录！ |
| 点击此处可从《药学研究》浏览原始摘要信息 |
|
点击此处可从《药学研究》下载免费的PDF全文 |
|
