| 阻塞性睡眠呼吸暂停与肿瘤的研究进展 |
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| 引用本文： | 梁小红,李艳,彭万达,宗赟. 阻塞性睡眠呼吸暂停与肿瘤的研究进展[J]. 山东大学耳鼻喉眼学报, 2017, 0(1): 70-74. DOI: 10.6040/j.issn.1673-3770.0.2016.533 |
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| 作者姓名： | 梁小红 李艳 彭万达 宗赟 |
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| 作者单位： | 苏州大学第三附属医院呼吸科,江苏常州,213000 |
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| 摘 要： | 近年来,许多流行病学研究发现阻塞性睡眠呼吸暂停(OSA)和肿瘤患病率存在相关性。大量动物实验和临床研究进一步证实OSA与肿瘤发生和进展相关,目前研究表明其机制主要涉及以下方面:氧化应激、炎症反应、交感神经兴奋性增高、免疫功能异常、外泌体、低氧诱导因子(HIF)等。
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| 关 键 词： | 睡眠呼吸暂停,阻塞性 肿瘤 流行病学研究 机制 |
Obstructive sleep apnea and cancer: a review |
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| LIANG Xiaohong,LI Yan,PENG Wanda,ZONG Yun. Obstructive sleep apnea and cancer: a review[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2017, 0(1): 70-74. DOI: 10.6040/j.issn.1673-3770.0.2016.533 |
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| Authors: | LIANG Xiaohong LI Yan PENG Wanda ZONG Yun |
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| Abstract: | Several studies have recently demonstrated that patients with obstructive sleep apnea (OSA) have a high prevalence of cancer and cancer-related mortality.A large number of animal experiments and clinical studies have further confirmed that OSA can be involved in tumorigenesis and progression.The mechanism may involve oxidative stress,systemic inflammation,sympathetic outflow,immune dysfunction,exosomes,hypoxia-inducible factor (HIF),and so on. |
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| Keywords: | Sleep apnea,obstructive Neoplasms Epidemiology Mechanism |
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