糠酸莫米松鼻喷剂联合玉屏风颗粒可提高儿童腺样体肥大疗效

目的 探讨糠酸莫米松鼻喷剂联合玉屏风颗粒治疗儿童腺样体肥大的疗效。 方法 采用前瞻性随机对照研究,对90例4~10岁腺样体肥大儿童单用糠酸莫米松鼻喷剂或联合玉屏风颗粒口服治疗8周,对比治疗前后患儿临床症状积分,内镜下观察腺样体变化,记录上呼吸道感染次数。 结果 对照组(鼻喷激素)临床症状总积分减少19.5%,鼻咽阻塞程度从82.2%下降到73.6%(P<0.01),上呼吸道感染次数大于1次者占44.19%;试验组(联合用药)临床症状总积分减少31.7%,鼻咽阻塞程度从85.4%下降到71.4%(P<0.01),上呼吸道感染次数>1次者占16.67%。 结论 糠酸莫米松鼻喷剂治疗儿童腺样体肥大有效,联合玉屏风颗粒可进一步提高疗效,并可减少儿童上呼吸道感染的发生率。

Efficacy of mometasone furoate and Yupingfeng particles for adenoid hypertrophy in children

Objective To explore the efficacy of Mometasone furoate and Yupingfeng particles in adenoid hypertrophy in children.Methods A total of 90 children aged 4-10 years completed 8 weeks treatment were enrolled in a prospective and randomized controlled study.The symptoms and degree of obstruction were evaluated by nasopharyngoscopy conducted pre-treatment and 8weeks post-treatment.Subjects received Mometasone furoate nasal spray alone at a daily dose of 200 μg or combination with Yupingfeng particles by a dose of 5 g twice a day for 8 weeks.Actual data were compared between the two groups.Results With Mometasone treatment,there was an 19.5 percent reduction in total clinical symptom score,and the degree of obstruction dropped from 82.2 to 73.6 percent(P ＜0.01).With Mometasone and Yupingfeng particles treatment,there was a 31.7 percent reduction in total clinical symptom score,and the degree of obstruction dropped from 85.4 to 71.4 percent(P ＜ 0.01).A statistically significant incidence of upper respiratory tract infection was seen in patients treated with Mometasone furoate nasal spray and Yupingfeng particles(16.7％) as compared with Mometasone alone (44.2％).Conclusion Mometasone furoate appears to be effective in treating children with adenoid hypertrophy.In combination with Yupingfeng particles,it can reduce the incidence of upper respiratory tract infection.