| 从纳米给药系统角度探讨阿尔茨海默病的治疗策略 |
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| 作者姓名： | 王立 梁爽 吕江维 薛冰 张文君 |
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| 作者单位： | 哈尔滨商业大学药学院,黑龙江 哈尔滨,150076 |
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| 基金项目： | 2016年哈尔滨商业大学青年创新人才支持项目(2016QN075) |
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| 摘 要： | 阿尔茨海默病严重威胁人类健康,主要是血脑屏障限制了药物到达作用靶点,影响阿尔茨海默病的治疗.而纳米给药系统为药物的脑靶向递送提供了可能,对阿尔茨海默病的治疗有改善作用,本文从阿尔茨海默病的发病机制和常规治疗药物展开,重点从纳米给药系统角度进行介绍阿尔茨海默病的治疗策略,概述几种典型的治疗阿尔茨海默病的纳米给药系统,即脂质体、聚合物胶束、固体脂质纳米粒和聚合物纳米粒等.
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| 关 键 词： | 阿尔茨海默病 纳米给药系统 脂质体 聚合物胶束 固体脂质纳米粒 聚合物纳米粒 |
Strategies for treatment of Alzheimer's disease from the perspective of nano-drug delivery system |
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| Authors: | WANG Li LIANG Shuang LYU Jiangwei XUE Bing and ZHANG Wenjun |
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| Institution: | School of Pharmacy,Harbin University of Commerce,Harbin 150076,China,School of Pharmacy,Harbin University of Commerce,Harbin 150076,China,School of Pharmacy,Harbin University of Commerce,Harbin 150076,China,School of Pharmacy,Harbin University of Commerce,Harbin 150076,China and School of Pharmacy,Harbin University of Commerce,Harbin 150076,China |
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| Abstract: | Alzheimer's disease is a serious threat to human health,mainly blood brain barrier limits the drug to reach the target and affects the treatment of Alzheimer's disease.The nano-drug delivery system for brain-targeted drug delivery offers the potential treatment and improvement for Alzheimer's disease.This article started from the pathogenesis and conventional therapeutic drugs of Alzheimer's disease,focusing from nano-drug delivery systemperspective to introduce the treatment strategies of Alzheimer's disease and summarized several typical treatment strategies of Alzheimer's disease nano-drug delivery systems,namely,liposomes,polymer micelles,solid lipid nanoparticles and polymer nanoparticles. |
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| Keywords: | Alzheimer's disease Nano-drug delivery system Liposomes Polymer micelles Solid lipid nanoparticles Polymer nanoparticles |
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