MGMT和EGFR蛋白在喉鳞状细胞癌中的表达及临床意义

目的 探讨喉鳞状细胞癌组织中O6-甲基鸟嘌呤DNA甲基转移酶(MGMT)、表皮生长因子受体(EGFR)的表达与临床病理特征及其相互之间的关系,研究其在肿瘤发生发展以及治疗中的作用。 方法 采用免疫组织化学染色法检测MGMT、EGFR的表达,分析103例喉癌组织标本与临床病理特征的关系。 结果 MGMT的表达与分化程度、T分期以及临床分期呈正相关(χ2为13.302、8.394、11.403,P值分别为0.001、0.039、0.010<0.05);EGFR的表达与T分期以及临床分期呈正相关(χ2为14.933、16.603,P值分别为0.002、 0.001<0.05)。分层分析发现,MGMT、EGFR 两者的表达强度存在正相关(χ2=5.369, P=0.019<0.05)。 结论 喉鳞状细胞癌中 MGMT、EGFR的表达与T分期、临床分期均有相关性,测定两者的表达水平可评估喉鳞状细胞癌的恶性程度并指导喉癌的治疗。

Expression and clinical value of MGMT and EGFR in laryngeal squamous cell carcinoma

Objective To investigate the relationship between expression of O6-methylguanine-DNA methyltransferase (MGMT) and epidermal growth factor receptor (EGFR) in laryngeal squamous cell carcinoma (LSCC),and their relationship with clinicopathological features.Methods We collected 103 tumor tissues,detected the expression of MGMT and EGFR by immunohistochemistry (IHC),and explored their relationship with the clinicopathological features.Results The expression of MGMT in tumor tissues was positively related to differentiation degree,T stage,and clinical stage (x2 13.302,8.394,11.403,P =0.001,0.039,and 0.010,respectively).The expression of EGFR in tumor tissue was positively correlated with T stage and clinical stage (x2 =14.933,16.603,P =0.002,and 0.001,respectively).Further analysis found that the expression levels of MGMT and EGFR were positively correlated (MGMT vs EGFRx2 =5.369,P =0.019).Conclusion The expression of MGMT and EGFR was correlated with T stage and clinical stage.Detecting their expression can assist in assessing the malignancy of LSCC and guide treatment.