| 内质网应激与炎症反应的研究进展 |
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| 引用本文： | 王镜淇,龚国清. 内质网应激与炎症反应的研究进展[J]. 药学研究, 2017, 36(5): 279-282. DOI: 10.13506/j.cnki.jpr.2017.05.009 |
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| 作者姓名： | 王镜淇 龚国清 |
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| 作者单位： | 中国药科大学药学院,江苏 南京,211198 |
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| 基金项目： | 国家自然科学基金(21472242) |
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| 摘 要： | 细胞应激状态会严重扰乱内质网功能,引起未折叠或错误折叠蛋白质在内质网腔内异常积聚.内质网通过3条信号通路组成的未折叠蛋白反应来维持内质网稳态.本文综述了近年来内质网应激与炎症反应通过多种机制相互偶联,调节机体内稳态平衡或参与多种炎性疾病的研究进展.这些研究有助于阐明内质网应激介导炎症反应的精确机制,为研发以内质网应激-未折叠蛋白反应-炎症反应为靶点的药物提供理论依据.
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| 关 键 词： | 内质网应激 未折叠蛋白反应 炎症反应 活性氧 核转录因子κB |
Research progress on endoplasmic reticulum stress and inflammatory response |
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| WANG Jingqi and GONG Guoqing. Research progress on endoplasmic reticulum stress and inflammatory response[J]. Journal of Pharmaceutical Research, 2017, 36(5): 279-282. DOI: 10.13506/j.cnki.jpr.2017.05.009 |
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| Authors: | WANG Jingqi and GONG Guoqing |
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| Affiliation: | Department of Pharmacology,China Pharmaceutical University,Nanjing 211198,China and Department of Pharmacology,China Pharmaceutical University,Nanjing 211198,China |
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| Abstract: | A variety of cellular stresses can severely perturb endoplasmic reticulum function,which cause pathological protein misfolding and aggregation within the ER.The unfolded protein response is a three-pronged signaling axis dedicated to preserving ER homeostasis.The paper reviewed the latest research progress on the complex interplay of ER stress,inflammation,and organismal homeostasis.Inflammation is both a cause and consequence of ER stress,and identifying additional signaling convergence points will guide the development of powerful therapeutics for inflammatory diseases and other UPR-mediated disorders with inflammatory components. |
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| Keywords: | Endoplasmic reticulum stress Unfolded protein response Inflammatory response ROS NF-κB |
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