| 苄基四氢巴马汀对迟后去极化,触发活动及兔希氏束电图的影响 |
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| 引用本文： | 姚伟星,夏国瑾.苄基四氢巴马汀对迟后去极化,触发活动及兔希氏束电图的影响[J].中国药理学报,1990,11(2):141-143. |
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| 作者姓名： | 姚伟星 夏国瑾 |
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| 摘 要： |
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| 关 键 词： | 四氢巴马汀 电生理学 希氏束 |
Effects of benzyltetrahydropalmatine on delayed after depolarization and triggered activity and rabbit His-bundle electrogram |
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| W X Yao,G J Xia,W Z Zeng,M X Jiang.Effects of benzyltetrahydropalmatine on delayed after depolarization and triggered activity and rabbit His-bundle electrogram[J].Acta Pharmacologica Sinica,1990,11(2):141-143. |
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| Authors: | W X Yao G J Xia W Z Zeng M X Jiang |
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| Institution: | Department of Pharmacology, Tongji Medical University, Hankou, China. |
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| Abstract: | Standard microelectrode techniques were used to study the effects of benzyltetrahydropalmatine (BTHP) on ouabain-induced delayed after depolarization (DAD) and triggered activity in isolated guinea pig papillary muscles. The results indicate that ouabain-induced DAD and triggered activity were abolished by BTHP 100 mumols/L. In anesthetized rabbit ECG heart rates were reduced in a dose-dependent manner from its control value of 288 +/- 14 to 261 +/- 14 (5 mg/kg) and 226 +/- 36 bpm (BTHP 10 mg/kg). P-R interval was prolonged. In His-bundle electrogram, H-V interval and V duration were not affected, but A-H interval was prolonged from 41 +/- 3 to 45 +/- 5 ms. |
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