| 阿苯达唑及其代谢物在人体内的药物动力学 |
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| 引用本文： | 关天颖,宫相义.阿苯达唑及其代谢物在人体内的药物动力学[J].中国药理学报,1990,11(1):69-72. |
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| 作者姓名： | 关天颖 宫相义 |
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| 摘 要： |
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| 关 键 词： | 阿苯达唑 药物动力学 高效液相色谱 |
Pharmacokinetics of albendazole and its metabolites in human body |
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| T Y Guan,X Y Gong,W Z Sun,S Z Liu,L F Zheng,M G Li.Pharmacokinetics of albendazole and its metabolites in human body[J].Acta Pharmacologica Sinica,1990,11(1):69-72. |
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| Authors: | T Y Guan X Y Gong W Z Sun S Z Liu L F Zheng M G Li |
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| Institution: | Division of Pharmacology, Jilin Agricultural University, Changchun, China. |
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| Abstract: | High-performance liquid chromatography method was used to determine blood sulfoxide and sulfone, two metabolites of albendazole. Methanol containing 0.4% acetic acid was employed as mobile phase. Wavelength of 290 nm was chosen for uv-detector and mebendazole was used as internal standard. After a single dosage of albendazole 25 mg/kg was taken orally by healthy volunteers and neurocysticercosis patients, sulfoxide and sulfone were found in blood at 20 and 40 min respectively. The blood peak level appeared at 6 h on an average. The metabolites remained as long as 58-72 h in human blood. |
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