| 锌离子对吡拉西坦促小鼠记忆作用的拮抗 |
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| 引用本文： | 朱桐君 陈醒言. 锌离子对吡拉西坦促小鼠记忆作用的拮抗[J]. 中国药理学报, 1990, 11(2): 100-102 |
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| 作者姓名： | 朱桐君 陈醒言 |
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| 摘 要： |
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| 关 键 词： | 吡拉西坦 锌 谷氨酸盐 学习 记忆 |
Antagonism of Zn2+ on nootropic action of piracetam in mice |
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| T J Zhu,X Y Chen,J C Pan,S S Zhang. Antagonism of Zn2+ on nootropic action of piracetam in mice[J]. Acta Pharmacologica Sinica, 1990, 11(2): 100-102 |
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| Authors: | T J Zhu X Y Chen J C Pan S S Zhang |
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| Affiliation: | Department of Pharmacology, Wenzhou Medical College, China. |
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| Abstract: | In mouse step-down test, the memory impairments of acquisition, consolidation and recognition were induced by anisodine, chloramphenical and ethanol, respectively. Piracetam 100 mg/(kg.d) ip for 5 d improved the anisodine-induced impairment of learning. ZnSO4 5 mg/(kg.d) po for 5 d did not improve the 3 impairments. Memory impairments were enhanced by a combined administration of ZnSO4 and piracetam in these 3 models. These results were confirmed by Y-maze method in normal mice. |
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