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| 针刺百会、大椎对拟血管性痴呆大鼠GSH-PX、CAT的影响 | |
| 引用本文： | 朱崇霞,张霁,程为平,原田俊英.针刺百会、大椎对拟血管性痴呆大鼠GSH-PX、CAT的影响[J].上海针灸杂志,2004,23(3):40-42. |
| 作者姓名： | 朱崇霞 张霁 程为平 原田俊英 |
| 作者单位： | 1. 黑龙江中医药大学,哈尔滨,150040 2. 黑龙江中医药大学附属第一医院神经内科主任 3. 日本广岛大学医学部神经内科 |
| 摘 要： | 目的 研究针刺百会、大椎穴对拟血管性痴呆(VD)大鼠的学习记忆行为及谷胱甘肽过氧化物酶(GSH—PX)、过氧化氢酶(CAT)的影响。方法 选用纯系Wistar老年大鼠36只，随机分为假手术组、模型组、针刺组和西药组，每组分别为9只。采用2—血管阻断法制成VD大鼠模型，共治疗30日，治疗后以大鼠穿梭箱实验成绩检测学习记忆行为情况，并检测脑内GSH—PX及CAT的活力。结果 针刺VD大鼠的百会大椎穴，可明显减少VD大鼠在穿梭箱实验中的电击次数和电击时间，脑内GSH—PX及CAT活力增强。结论针刺百会，大椎穴能提高VD大鼠的学习记忆能力，并能改善自由基的代谢。 |
| 关 键 词： | 百会穴 大椎穴 血管性痴呆 大鼠 GSH-PX CAT 学习记忆行为 自由基 |
| 文章编号： | 1005-0957(2004)03-0040-03 |
| 修稿时间： | 2003年10月27 |
The Influence of Needling Baihui and Dazhui on GSH-PX and CAT in A Rat Model of Vascular Dementia |
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| ZHU Chongxia ,ZHANG Ji ,CHENG Wei ping ,Harata . .Helongjiang University of Traditional Chinese Medicine,Harbin ,China.The Influence of Needling Baihui and Dazhui on GSH-PX and CAT in A Rat Model of Vascular Dementia[J].Shanghai Journal of Acupuncture and Moxibustion,2004,23(3):40-42. | |
| Authors: | ZHU Chongxia ZHANG Ji CHENG Wei ping Harata Helongjiang University of Traditional Chinese Medicine Harbin China |
| Institution: | ZHU Chongxia 1,ZHANG Ji 1,CHENG Wei ping 2,Harata 3. 1.Helongjiang University of Traditional Chinese Medicine,Harbin 150040,China, 2. Department of Neurology,First Hospital Affiliated to Helongjiang University of Traditional Chinese Medicine,China, 3. Department of Neurology,Medical School,Hurosima University,Japan |
| Abstract: | Purpose To investigate the influence of needling Baihui and Dazhui on learning, memory, glutathion peroxidase (GSH PX) and catalase (CAT) in a rat model of vascular dementia (VD). Methods Thirty six Wester rats were randomly divided into sham operation, model, acupuncture and Western medicine groups, 9 rats each group. A rat VD model was made by vessel occlusion and treated for 30 days. Rat's learning ability and memory were tested with a rat running box and intracerebral activity of GSH PX and CAT was determined. Results Needling points Baihui and Dazhui markedly decreased the number and time of electric shock to a VD rat in a running box experiment and increased the activity of GSH PX and CAT. Conclusion Needling points Baihui and Dazhui can improve learning ability and memory, and free radical metabolism in VD rats. |
| Keywords: | Rat VD model Acupuncture Glutathion peroxidase Catalase |
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