| 抗癌新靶点及其靶向药物的研究现状 |
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| 引用本文： | 刘文虎,贺殿,胥桂贤. 抗癌新靶点及其靶向药物的研究现状[J]. 药学进展, 2007, 31(12): 535-542 |
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| 作者姓名： | 刘文虎 贺殿 胥桂贤 |
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| 作者单位： | 兰州大学药学院药物化学研究所,甘肃,兰州,730000 |
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| 摘 要： | 综述近年来抗癌新靶点及其靶向药物的研究进展，其中包括与细胞信号转导有关的蛋白酪氨酸激酶、蛋白激酶C、法尼基转移酶、丝裂原激活的蛋白激酶等靶点和基质金属蛋白酶、拓扑异构酶、微管、G四螺旋、热休克蛋白90等靶点及其靶向抗癌药的发现与研究。
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| 关 键 词： | 抗癌靶点 细胞信号转导 细胞增殖 细胞凋亡 靶向药物 |
| 文章编号： | 1001-5094（2007）12-0535-08 |
| 收稿时间： | 2007-08-13 |
Current Status of Novel Anti-tumor Targets and Their Targeting Drugs |
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| LIU Wen-hu,HE Dian,XU Gui-xian. Current Status of Novel Anti-tumor Targets and Their Targeting Drugs[J]. Progress in Pharmaceutical Sciences, 2007, 31(12): 535-542 |
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| Authors: | LIU Wen-hu HE Dian XU Gui-xian |
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| Abstract: | The recent advances on novel anti-tumor targets and their targeting drugs, including discovery and research of the targets related to cellular signaling, such as PTK, PKC, FFase and MAPK, and other targets, such as MMPs, Topo, Microtubule, G-quadruplex and HSP90, and the targeting anti-tumor drugs thereof, were reviewed. |
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| Keywords: | Anti-tumor target Cellular signaling Cell proliferation Cell apoptosis Targeting drug |
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