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Regulator of G protein signaling 2 is a key modulator of airway hyperresponsiveness

Authors:	Yan Xie Haihong Jiang Hoai Nguyen Shuping Jia Abdo Berro Reynold A. Panettieri Jr. Dennis W. Wolff Peter W. Abel Thomas B. Casale Yaping Tu

Affiliation:	^a Department of Pharmacology, Creighton University School of Medicine, Omaha, Neb ^b Department of Internal Medicine, Creighton University School of Medicine, Omaha, Neb ^c Pulmonary, Allergy and Critical Care Division, Airways Biology Initiative, University of Pennsylvania, Philadelphia, Pa

Abstract:

Keywords:	Asthma airway hyperresponsiveness airway smooth muscle mass airway smooth muscle contraction Ca²⁺ mobilization extracellular signal-regulated kinase G protein-coupled receptors knockout mice ovalbumin-sensitized/-challenged murine model of asthma phosphatidylinositol 3-kinase regulator of G protein signaling 2
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