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Islet-cell antibodies and beta-cell function in insulin-dependent diabetics |
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| Authors: | S. Madsbad G. F. Bottazzo A. G. Cudworth B. Dean O. K. Faber C. Binder |
| Affiliation: | (1) Present address: Steno Memorial Hospital, Gentofte, Denmark;(2) Hvidøre Hospital, Klampenborg, Denmark;(3) Department of Immunology, The Middlesex Hospital Medical School, UK;(4) Department of Medicine, St. Bartholomew's Hospital, London, England |
| Abstract: | Summary Residual insulin secretion and islet-cell antibodies were studied in 399 insulin-dependent diabetics with age at onset of between 10–19.9 years (248 patients) or 30–39.9 years (151 patients). We found the prevalence of islet-cell antibodies to be independent of residual beta-cell function as measured by serum C-peptide and age at onset. The cause and role of the persistence of islet-cell antibodies in insulin-dependent diabetics remain obscure. |
| Keywords: | Insulin-dependent diabetics beta-cell function islet-cell antibodies |
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