同型半胱氨酸对脑卒中后抑郁恢复的影响

目的：探讨同型半胱氨酸（Hcy）对脑卒中后抑郁恢复的影响。方法：纳入100例我院2010年12月～2013年3月确诊为脑卒中后抑郁的患者（A组）,同时随机抽取100例脑卒中后未发生抑郁的患者（B组）及100例门诊体检的健康人群（C组）。对所有受试者的认知功能进行评价,同时空腹抽取肘静脉血检测Hcy水平。结果：A、B及C组临床痴呆评定量表（CDR）评分分别为（2.66±0.63）、（2.34±0.55）、（1.63±0.54）分,简易精神状态量表（MMSE）评分分别为（19.35±3.53）、（21.04±3.54）、（25.63±3.25）分,3组比较差异均有统计学意义（P〈0.05）。A组Hcy水平（24.24±6.14）μmol/L]及高同型半胱氨酸血症（HH）例数34.0%]明显高于B组（18.25±5.42）μmol/L,17.0%]和C组（12.66±3.23）μmol/L,3.0%,]差异均有统计学意义（P〈0.05）。相关分析显示：随Hcy水平的升高,CDR评分升高,两者呈正相关,而MMSE评分下降,两者呈负相关;同样CDR评分与HH亦呈正相关,而MMSE评分与HH呈负相关。结论：脑卒中后抑郁患者的认知功能受血清Hcy水平的影响,随Hcy水平的升高,该类患者的认知功能随之下降,因此临床可通过早期检测Hcy水平并及时给予对症治疗。

Influence of plasma levels of homocysteine on patients with post-stoke depression

Objective：To investigate the influence of plasma homocysteine（Hcy）on patients with post-stroke depression.Methods：A total of 100cases with post-stroke depression after cerebral infarction were enrolled（group A）and 100cases with simple cerebral infarction（group B）and 100healthy volunteers（group C）were also selected as normal control subjects.Plasma Hcy were measured and the cognitive function evaluated in all subjects and compared between the three groups.Results：CDR scores in three group were（2.66±0.63）points,（2.34±0.55）points,（1.63±0.54）points,respectively.MMSE scores were（19.35±3.53）points,（21.04±3.54）points,（25.63±3.25）points,respectively showing significant differences among the three groups.Hcy levels in group A was（24.24±6.14）μmol/L,significant higher than（18.25±5.42）μmol/L and（12.66±3.23）μmol/L of group B and C.The number of hyperhomocysteinemia（HH）cases in three group were 34（34.0%）,17（17.0%）,3（3.0%）,respectively showing significant difference among the three groups（P0.05）.Hcy level and CDR score were positively correlated.But Hcy level and MMSE score were negatively correlated,HH score were positively correlated with CDR but negatively correlated with MMSE.Conclusion：Cognitive function of patients with poststroke depression might be influenced by Hcy level,it decreased with Hcy level,thus detecting Hcy level is helpfly for treating post-stroke depression cognitive dysfunction.