Interventions for fatigue in Parkinson's disease: A systematic review and meta‐analysis |
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| Authors: | Marloes Franssen MSc Charlotte Winward MSc PhD Johnny Collett PhD Derick Wade MD FRCP Helen Dawes MMedSci PhD |
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| Affiliation: | 1. Movement Science Group, Oxford Brookes University, , Oxford, United Kingdom;2. Therapies, Oxford University Hospitals, NHS Trust, , Oxford, United Kingdom;3. Oxford Centre for Enablement, , Oxford, United Kingdom |
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| Abstract: | The authors sought to review the efficacy of interventions for fatigue in Parkinson's disease. A search was conducted of PubMed, Cinahl, Psychinfo, EMBASE, and Web of Knowledge up to November 2013. Methodological quality was assessed using the PEDro scale. For meta‐analyses, studies were weighted on variance. Effect sizes were calculated with 95% confidence interval (CI); overall effect was presented by means of a Z‐score; heterogeneity was investigated using the I2. Fourteen articles (n = 1,890) investigating drugs and behavioral therapy were eligible. Ten studies demonstrated excellent, three good, and one fair methodological quality. Three articles (investigating amphetamines) were appropriate for meta‐analysis, which was performed according to scales used: Multidimensional Fatigue Inventory: mean difference, –6.13 (95%CI: –14.63‐2.37, Z = 1.41, P = 0.16; I2 = 0); Fatigue Severity Scale: mean difference, –4.00 (95%CI: –8.72‐0.72, Z = 1.66, P = 0.10; I2 = 0). Currently insufficient evidence exists to support the treatment of fatigue in PD with any drug or nondrug treatment. Further study is required. © 2014 International Parkinson and Movement Disorder Society |
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| Keywords: | Parkinson's disease fatigue meta‐analysis dopamine amphetamines |
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