Plasma levels of soluble tumor necrosis factor receptors are associated with cognitive performance in Parkinson's disease |
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| Authors: | Natália Pessoa Rocha MSc Antônio Lúcio Teixeira MD PhD Paula Luciana Scalzo PhD Izabela Guimarães Barbosa MD PhD Mariana Soares de Sousa MD Isabela Boechat Morato Érica Leandro Marciano Vieira PhD Paulo Pereira Christo MD PhD András Palotás MD PhD Helton José Reis PhD |
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| Affiliation: | 1. Laboratório Interdisciplinar de Investiga??o Médica, Faculdade de Medicina, Universidade Federal de Minas Gerais, , Belo Horizonte, Minas Gerais, Brazil;2. Laboratório de Neurofarmacologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, , Belo Horizonte, Minas Gerais, Brazil;3. Laboratório de Neurobiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, , Belo Horizonte, Minas Gerais, Brazil;4. Departamento de Neurologia e Neurocirugia, Santa Casa de Belo Horizonte Hospital, , Belo Horizonte, Minas Gerais, Brazil;5. Asklepios‐Med (private medical practice and research center), , Szeged, Hungary |
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| Abstract: | Inflammatory mechanisms have been implicated in a series of neuropsychiatric conditions, including behavioral disturbances, cognitive dysfunction, and affective disorders. Accumulating evidence also strongly suggests their involvement in the pathophysiology of Parkinson's disease (PD). This study aimed to evaluate plasma levels of inflammatory biomarkers, and their association with cognitive performance and other non‐motor symptoms of PD. PD patients and control individuals were subjected to various psychometric tests, including the Mini‐Mental State Examination (MMSE), Frontal Assessment Battery (FAB), and Beck's Depression Inventory (BDI). Biomarker plasma levels were measured by enzyme‐linked immunosorbent assay (ELISA). PD patients exhibited worse performance on MMSE and the programming task of FAB, and presented higher soluble tumor necrosis factor receptor (sTNFR) plasma levels than control individuals. Among PD patients, increased sTNFR1 and sTNFR2 concentrations were associated with poorer cognitive test scores. After multiple linear regression, sTNFR1 and education remained a significant predictor for FAB scores. Our data suggest that PD is associated with a proinflammatory profile, and sTNFRs are putative biomarkers of cognitive performance, with elevated sTNFR1 levels predicting poorer executive functioning in PD patients. © 2013 International Parkinson and Movement Disorder Society |
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| Keywords: | cognition inflammation non‐motor symptoms Parkinson's disease tumor necrosis factor |
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