| 舒芬太尼对大鼠缺血再灌注损伤心肌的保护作用 |
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| 引用本文： | 陈中青,贾绍斌,张冬梅.舒芬太尼对大鼠缺血再灌注损伤心肌的保护作用[J].宁夏医科大学学报,2011(10):920-923. |
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| 作者姓名： | 陈中青 贾绍斌 张冬梅 |
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| 作者单位： | 宁夏医科大学总医院心脏中心; |
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| 摘 要： | 目的观察舒芬太尼对大鼠急性缺血再灌注损伤心肌（I/R）的保护作用。方法建立72只大鼠心肌缺血再灌注损伤模型,随机分为假手术组（sham组）、缺血再灌注对照组（I-R组）、缺血预处理组（IPC组）和舒芬太尼不同剂量预处理组（SPC1、SPC2、SPC3组）,分别以0.25、1、5μg.kg-1静脉泵注5min,停止5min,重复进行3次。于缺血前30min、缺血30min、再灌注90 min时记录左室内压峰值（LVSP）,以及左心室收缩及舒张最大压力变化速率（±dp/dtmax）。再灌注90min时取出大鼠心脏,并取结扎线以下的心室壁心肌组织行病理学电镜检查。结果与sham组比较,I-R组、IPC、SPC1、SPC2和SPC3组LVSP及±dp/dtmax降低（P〈0.01）,心肌超微结构不同程度损伤;与I-R组比较,IPC组、SPC1、SPC2、SPC3组LVSP及±dp/dtmax升高（P〈0.01）,心肌组织超微结构损伤减轻。结论舒芬太尼可对大鼠急性心肌缺血再灌注损伤心肌产生保护效应。
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| 关 键 词： | 舒芬太尼 预处理 急性心肌缺血 心肌再灌注损伤 |
Protective Effects of Sufentanil on Acute Myocardial Ischemia/reperfusion Injury in Rats |
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| CHEN Zhong-qing,JIA Shao-bin,ZHANG Dong-mei.Protective Effects of Sufentanil on Acute Myocardial Ischemia/reperfusion Injury in Rats[J].Journal of Ningxia Medical College,2011(10):920-923. |
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| Authors: | CHEN Zhong-qing JIA Shao-bin ZHANG Dong-mei |
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| Institution: | CHEN Zhong-qing,JIA Shao-bin,ZHANG Dong-mei(Center of Cardiology,The General Hospital of Ningxia Medical University,Yinchuan 750004) |
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| Abstract: | Objective To explore the protective effects of sufentanil precondition on myocardium ischemia/reperfusion(I/R) injury.Methods The myocardial idchemia and reperfusion injury model was established.The animals were randomly divided into 4 groups: sham operation group(sham,n=12);ischemia-reperfusion control group(I-R,n=12);ischemic preconditioning group(IPC,n=12)and sufentanil preconditioning group which was further divided into 3 subgroups according to the dose of sufentanil(SPC).In I-R group the hearts were s... |
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| Keywords: | sufentanil preconditioning acute myocardial infarction myocardial reperfusion injury |
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