哌拉西林钠对甲磺酸帕珠沙星在大鼠体内药代动力学的影响

目的研究哌拉西林钠对甲磺酸帕珠沙星在大鼠体内药代动力学的影响。方法 12只健康雄性SD大鼠随机分成2组(分别为单独和联合给药组),用HPLC法测定血浆中甲磺酸帕珠沙星的浓度。结果单独用药与联合用药组ρmax分别为(33.54±4.68)和(37.83±3.43)mg.L-1,AUC0-t分别为(43.32±15.91)和(41.98±9.19)mg.h.L-1,t1/2分别为(1.00±0.31)和(0.80±0.24)h,无显著性差异(P>0.05)。结论与哌拉西林钠联合用药后甲磺酸帕珠沙星在大鼠体内的药动学参数均不存在显著性差异。

Effect of piperacillin sodium on pharmacokinetics of pazufloxacin mesilate in rats

Objective To investigate the effect of piperacillin sodium on pharmacokinetics of pazufloxacin mesilate in rats.Methods Twelve healthy male SD rats were divided into two groups(i.v.pazufloxacin mesilate alone and combination of piperacillin sodium and pazufloxacin mesilate),the plasma concentrations of pazufloxacin mesilate were determined by HPLC.Results The pharmacokinetics parameters of pazufloxacin mesilate in healthy rats after i.v.pazufloxacin mesilate alone and combination of piperacillin sodium and pazufloxacin mesilate were as follow:ρmax were(33.54±4.68) and(37.83±3.43)mg · L-1,AUC0-t were(43.32±15.91) and(41.98±9.19)mg · h · L-1;t1/2 were(1.00±0.31) and(0.80±0.24)h,which showed no significance difference between the two groups(P>0.05).Conclusions There are no significant differences about pharmacokinetic parameters between pazufloxacin mesilate alone and combination of piperacillin sodium in SD rats.