Glabridin from Chinese Herb Licorice Inhibits Fatigue in Mice |
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| Authors: | Huaping Shang Shehua Cao Jihui Wang Hua Zheng Ramesh Putheti |
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| Affiliation: | 1East China Jiaotong University, Nanchang City, Jiangxi Province, 330013, P.R. China;2Guangxi Teachers Education University, Nanning City, Guangxi Province, 230023, P.R. China;3Shangrao Normal University, Shangrao City, Jiangxi Province, 334001, P.R. China;4Member, American Association of Pharmaceutical Scientists (AAPS), 236-203, Saint David Court, Maryland, USA |
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| Abstract: | The inhibiting effect of glabridin from Chinese herb Licorice on fatigue was investigated in male BALB/c mice. Mice were divided into the following 4 experimental groups: control group (CG), low dose group (LG), middle dose group (MG) and high dose group (HG,). The control group was given 0.5% Tween 80 solution and the treatment groups (LG, MG, HG) were given various doses of glabridin (5, 10, 20 mg/kg) for 28 consecutive days. Body mass, blood lactic acid (BLA), serum blood urea nitrogen (BUN), liver glycogen and muscle glycogen concentrations in mice were determined. Results showed that glabridin significantly inhibited fatigue, which extended the exhaustive exercise time of mice, effectively delayed the elevation of blood lactic acid and increase in the storage of liver and muscle glycogen. |
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| Keywords: | glabridin inhibits fatigue mice |
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