Natural selection in neoplastic progression of Barrett's esophagus |
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Authors: | Maley Carlo C Reid Brian J |
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Affiliation: | Molecular and Cellular Oncogenesis Program, The Wistar Institute, 3601 Spruce St., Philadelphia, PA 19104, USA. cmaley@alum.mit.edu |
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Abstract: | Neoplasms progress to cancer through a process of natural selection. The rate of evolution, and thus progression is determined by three parameters: mutation rate, population size of the evolving neoplastic cells, and intensity of selection or rate of clonal expansion. All three parameters are reviewed in the context of Barrett's esophagus, a pre-malignant neoplasm. Although Barrett's esophagus is an ideal model for the study of neoplastic clonal evolution, similar studies may be carried out in a wide variety of human neoplasms. Evolutionary analyses provide insights for clinical management, including rates of progression to cancer and emergence of resistance to interventions. |
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Keywords: | Neoplastic progression Natural selection Barrett's esophagus Evolution Cancer |
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