实验性晕船对动物脑体功能的影响

目的研究实验性晕船对动物体能和脑功能的影响并探讨其相关机理。方法取小鼠20只,随机分为对照组和晕船模型组;另取小鼠60只,分为轻、中、重3种程度晕船组及其相应对照组,观察不同强度模拟晕船刺激后各组学习和记忆成绩以及游泳时间的变化;取大鼠20只,随机分为晕船组和对照组,观察模拟晕船刺激对其血糖、乳酸、糖原等生化指标的影响。结果模拟晕船刺激可显著降低小鼠学习和记忆成绩以及游泳时间,刺激强度越大,下降程度亦越大,重度晕船组小鼠学习、记忆以及游泳时间分别较对照组降低23%(P<0.01)、17%(P<0.05)、42%(P<0.01);模拟晕船刺激后大鼠血糖显著升高,肝糖原和肌糖原含量显著下降,血清和大脑乳酸浓度显著升高,肌肉乳酸含量下降(P<0.05,P<0.01)。结论实验性晕船动物脑体功能下降,其下降程度随刺激强度增加而加重,其机理可能与糖原储备降低及大脑能量代谢异常有关。

EFFECT OF EXPERIMENTAL SEASICKNESS ON PHYSICAL AND MENTAL PERFORMANCE OF ANIMALS

Objective To explore the effect of experimental seasickness on physical and mental performance and its possible mechanism in mice and rats. Methods Twenty mice were divided into two groups to detect the mice pica. Sixty rats were divided into six groups: low,middle and high degree of seasickness groups and their corresponding control groups. Their learning and memory ability, swimming time were examined. Twenty rats (experimental seasickness group, n=10, and control group,n=10) were used to measure the contents of serum glucose, glycogen, and lactate. Results The simulated seasickness stimulation could decrease the mice learning and memory ability, and swimming time. The learning and memory ability, and swimming time were 23% (P<0.01), 17% (P<0.05), and 42% (P<0.01) lower respectively in high degree seasickness group than in the control group. In experimental seasickness rats, the levels of blood glucose, serum and cerebral lactate were significantly increased while the contents of muscle lactate, liver and muscle glycogen were significantly decreased (P<0.05, P<0.01). Conclusion The physical and mental performance of animals suffered from experimental seasickness were decreased, which was aggravated with the increasing degree of seasickness. The mechanism may be related to the decrease in glycogen storage and the disturbance in cerebral energy metabolism.