Potency of inactivated poliovirus vaccines. Correlation between antigenic extinction limit titers in guinea pigs and results obtained in man |
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| Authors: | S. Gard T. Johnson E. Lycke B. Melén G. Olin R. Salenstedt G. Wrange |
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| Affiliation: | (1) Department of Virus Research, Karolinska Institutet Medical School, Stockholm, Sweden;(2) State Bacteriological Laboratory, Stockholm, Sweden |
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| Abstract: | Summary Antibody responses to four different inactivated poliovirus vaccines were studied in 617 school children without preimmunization antibodies to any type. The results obtained showed a mathematically definable correlation to the antigenic extinction limit titers in guinea pigs of the same vaccines. The pattern of response to the type 2 antigen differed distinctly from those of types 1 and 3.This study was aided by grants from Konung Gustaf V: s 80-årsfond. |
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