他克莫司软膏治疗酒渣鼻临床疗效观察

目的观察外用0.03%他克莫司软膏治疗酒渣鼻的临床疗效和安全性。方法入选的40例酒渣鼻患者均外用0.03%他克莫司软膏,2次/d,共4w。于治疗前及治疗后第1、2、3和4周时各随访1次。结果40例患者中31例完成临床试验。治疗后第1、2、3和4周时治疗红斑有效率分别为32.26%、61.29%、74.19%和83.87%;而丘疹和脓疱的有效率分别为9.68%、22.58%、25.81%和38.71%。0.03%他克莫司软膏对表现为红斑的酒渣鼻患者的疗效优于表现为丘疹和脓疱者。在治疗3～5天时29.03%的患者出现局部刺激反应。结论他克莫司软膏治疗酒渣鼻安全有效,对以红斑为主要临床表现的酒渣鼻患者的疗效较好。

Clinical Efficacy of Opical Tacrolimns Ointment in Treating Rnsacea

Objective To investigate the clinical efficacy and safety of topical tacrolimus ointment 0.03% in the treatment of patients with facial rosacea.Methods Forty patients were treated with topical tacrolimus ointment0.03% twice a day,and the scores of the clinical symptom and sign scores were measured before and after the treatment.Meanwhile the adverse reaction were observed.Results Thirtyty-one of 40 cases completed the whole course of treatment.Marked effective rates were 32.26%,61.29%、74.19% and 83.87% respectively on the 7th day,14th day,21th day,28th day after the treatment in erythema respectively,while marked effective rates were 9.68%,22.58%,25.81%,38.71% in papules and pustules.Among avariety of skin lesions,the therapeutic effect was better for erythema lesions than that for inflammatory papules and pustules,Of the 31 patients,9cases(29.03%) were reported to have local burning and itching after the treatment in the first weeks treatment.Conclusions Tacrolimus ointment 0.03% may be a safe and effective treatment option for the patients with rosacea,but it is necessary to further investigate the therapeutic effect in various skin lesions.