Linkage of essential hypertension to chromosome 18q |
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Authors: | Kristjansson Kristleifur Manolescu Andrei Kristinsson Arni Hardarson Thordur Knudsen Helga Ingason Sigurdur Thorleifsson Gudmar Frigge Michael L Kong Augustine Gulcher Jeffrey R Stefansson Kari |
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Institution: | deCODE genetics, Inc, Reykjavik, Iceland. kris@ decode.is |
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Abstract: | We performed a genomewide scan with 904 microsatellite markers using 120 extended Icelandic families with 490 hypertensive patients. The families were identified by cross-matching a list of hypertensive patients from the Hypertension Clinic of the University Hospital (Landspitalinn) in Iceland with a genealogy database of the entire Icelandic nation. After adding 5 markers, we found linkage to chromosome 18q with an allele-sharing LOD score of 4.60 (P=2.1x 10(-6)). These results provide evidence for a novel susceptibility gene for essential hypertension on chromosome 18q and show that it is possible to study the genetics of essential hypertension without stratifying by subphenotypes. |
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