| 磁性顺铂微球的药物控释研究 |
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| 引用本文： | 王平康,王光志,马锦琦. 磁性顺铂微球的药物控释研究[J]. 中国药学杂志, 1998, 33(9): 537-540 |
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| 作者姓名： | 王平康 王光志 马锦琦 |
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| 作者单位： | 洛阳医学高等专科学校 |
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| 摘 要： | 目的：改善磁性顺铂微球的药物突释和滞释，实现控释。方法：用不同的工艺制备磁性顺铂微球并进行体外、体内药物释放的测定。结果：当高分子骨架材料中，疏水性纤维多糖-含水解键的苯酐聚合物=7：3，搅拌速度1500r·min-1，成型温度20℃时，制备的磁性顺铂微球具有较好的控释特性。结论：对开发磁性微球和导向治疗恶性肿瘤有实际意义。
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| 关 键 词： | 磁性 微球 顺铂 突释 滞释 控释 肿瘤 |
| 收稿时间： | 1997-07-18; |
Study on drug controlled release of magnetic cisplatin microspheres |
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| (. Study on drug controlled release of magnetic cisplatin microspheres[J]. Chinese Pharmaceutical Journal, 1998, 33(9): 537-540 |
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| Authors: | ( |
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| Affiliation: | (wang PK)，Wang Guangzhi(Wang GZ)，Ma Jinqi(Ma JQ)，et a |
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| Abstract: | OBJECTIVE: To improve drug burst release and stagnant release of magnetic cisplatin microspheres (MCM). METHODS: Preparing MCM by different crafts and determining drug in vivo and in vitro release. RESULTS: The prepared MCM could achieve controlled release effectively when the ratio of hydrophobic skeleton materials to cross link coincident materials with hydrolytic bond in the polymeric substratum materials was seven to three, the stirring speed was 1 500 r·min-1, and the shaping temperature was 20 ℃. CONCLUSION: It is important to develop magnetic microspheres for treating malignant tumours. |
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| Keywords: | magnetie microspheres cisplatin burst release stagnant release controlled release malignant tumours |
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