白藜芦醇苷对缺氧性肺动脉高压的作用

目的研究白藜芦醇苷对急性缺氧性肺动脉高压的血流动力学、纤溶系统及肺功能的作用.方法建立猪缺氧性肺动脉高压模型,观察静脉注射白藜芦醇苷前后的血液动力学、肺功能及血中纤溶指标的变化,并与对照组比较.结果用白藜芦醇苷后肺动脉压与用药前比较及与对照组比较均有显著下降(P＜0.01);心搏指数与对照组比较有所增加(P＜0.05);组织型纤溶酶原激活剂(t-PA)与用药前比较及与对照组比较有所增加(P＜0.05),血浆纤溶酶原激活剂抑制物的含量(PAI)与用药前比较及与对照组比较有所下降(P＜0.05).结论白藜芦醇苷可明显降低缺氧引起的肺动脉高压,增加心输出量,增强纤溶系统活性.

Effectiveness of polydatin on hypoxic pulmonary hypertension

Objective To investigate the effect of polydatin on hemodynamic, fibrinolysis system and lung function in animals with acute hypoxic puhnonary hypertension. Methods The acute hypoxic pulmonary hypertension of pigs were established. Indices of hemodynalnic and fibrinolysis and lung function were detected before and after treating polydatin in experimental pigs. While the same indices were detected in controls. Results After infusing introvanously polydatin injection ,the mean value of puhnonary artery pressure was significantly decreased than that before therapy in pigs and in controls (P<0.01);Cardiac Index was increased in treatment groups than that in controls(P<0.05); The mean value of t-PA was increased than that both before therapy in pigs and in controls (P<0.05); The mean value of PAI was decreased than that both before therapy in pigs and in controls (P<0.05). Conclusions The results suggest that polydatin could significantly decline the pulmonary artery pressure in hypoxic animals, and it could increase the cardiac output and improve tile fibrinolitic activity.