A unique pattern of lymphokine synthesis is a characteristic of certain antigen-specific suppressor T cell clones |
| |
Authors: | Nanda Navreet K; Sercarz Eli E; Hsu Di-Hwel; Kronenberg Mitchell |
| |
Institution: | 1 Departments of Microbiology and Molecular Genetics and Microbiology and immunology UCLA, Los Angeles, CA 90024, USA
2 Jonsson Comprehensive Cancer Center UCLA, Los Angeles, CA 90024, USA
3 lmmuLogic Pharmaceutical Corporation Palo Alto, CA 94304, USA |
| |
Abstract: | We report that the lymphokines (IFN- ) and IL-10 are co-syntheslzedby previously described CD3+ TCR ß+, minor antigen-specificsuppressor T cell clones. IFN- and IL-10 are known to (I) becharacteristically produced by different helper T cell types,Th1 and Th2 respectively, and (II) inhibit the function of thereciprocal subset of T cells: IFN- Inhibits the function ofTh2 and IL-10 that of Th1 cells. Although Th0 cells are alsoknown to synthesize cytoklnes of both the Th1- and Th2-typeT cells, the suppressor T cells described in this report aredifferent from Th0 cells in that they produce (I) neither IL-2nor IL-4 molecules and (II) stimulation via their CD3-TCR systemseems independent of both IL-2 and IL-4, the typical autocrinemolecules for T cell proliferation. The lymphokine profile ofthese suppressor T (TJ cell clones, as well as those of humanantigen-specific T. cells reported earlier, suggests that co-synthesisof some Th1-llke and some Th2-like cytoklnes may be a characteristicof antigen-specific T, cells as opposed to the type of reciprocalinhibition mediated through IFN- or IL-10, which is antigennon-specific. |
| |
Keywords: | CD4 CD8 IFN- " target="_blank">gif" ALT="{gamma}" BORDER="0"> IL-10 lymphokines suppressor T cells |
本文献已被 Oxford 等数据库收录! |
|