Regulation and role of transforming growth factor-β in immune tolerance induction and inflammation |
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| Authors: | Carsten B Schmidt-Weber Kurt Blaser |
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| Affiliation: | Swiss Institute of Allergy and Asthma Research, Obere Strasse 22, CH-7270 Davos, Switzerland. csweber@siaf.unizh.ch |
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| Abstract: | Transforming growth factor-beta (TGF-beta) is known to mediate pleiotropic functions both inside and outside the immune system. Recent progress in this field underlines the role of TGF-beta in regulatory T (Treg) cells, where it participates in both suppression and differentiation. In addition, recent information highlights the role of TGF-beta in repair responses that lead to matrix deposition and tissue remodelling. Many chronic inflammatory diseases, such as asthma, profit from the suppression of specific immune responses by TGF-beta; however, TGF-beta-mediated tissue remodelling can be a serious complication in such diseases. |
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| Keywords: | Abbreviations: BMP, bone morphogenetic protein DC, dendritic cell IL, interleukin PKA, protein kinase A TGF-β, transforming growth factor-β Th cell, T helper cell Treg cell, regulatory T cell SARA, SMAD anchor for receptor activation SMA, smooth muscle isoform of α-actin |
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