| 骨桥蛋白在雄性哺乳动物生殖系统中的作用 |
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| 引用本文： | 刘倩. 骨桥蛋白在雄性哺乳动物生殖系统中的作用[J]. 中华男科学杂志, 2012, 18(5): 446-449 |
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| 作者姓名： | 刘倩 |
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| 作者单位： | 武汉大学人民医院生殖医学中心,湖北武汉,430060 |
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| 摘 要： | 骨桥蛋白(OPN)为一种多功能的细胞外基质蛋白,在多种组织及体液中广泛表达,参与各项生理及病理过程。同时,OPN也表达于女性及男性的生殖系统,参与了胚胎的着床、生长发育及分化等生殖过程。近年来研究表明,OPN普遍存在于雄性哺乳动物的生殖系统中,并与雄性动物的生育力有着密切的关系,可能影响精子的质量及其受精过程等。对OPN相关功能的研究将有助于解释男性不育的机制,提高辅助生殖技术的成功率。
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| 关 键 词： | 骨桥蛋白 生殖 男性生育 睾丸 附睾 精子 |
Osteopontin and male reproduction |
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| LIU Qian. Osteopontin and male reproduction[J]. National journal of andrology, 2012, 18(5): 446-449 |
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| Authors: | LIU Qian |
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| Affiliation: | Center for Reproductive Medicine, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, China. |
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| Abstract: | Osteopontin (OPN) is an extracellular matrix protein with multifunctions, expressed in various tissues and body fluids, involved in various physiological and pathological processes. It is also detected in the reproductive tract of both males and females, and participates in the implantation, development and differentiation of embryos. Recent studies have indicated that OPN is closely related with male fertility and may affect sperm quality and fertilization. An insight into the functions of OPN may help to explain the mechanisms of male infertility and improve the success rate of assisted reproductive technology. |
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| Keywords: | osteopontin reproduction male fertility testis epididymis sperm |
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