血小板蛋白质组学的研究进展

人类血液中的血小板在各种生命过程中扮演重要角色,并广泛参与人体的各种生物过程,如血栓、炎症、伤口愈合和血栓形成等。血小板无细胞核,因而对它的研究无法采用传统的细胞和分子生物学方法。相比之下,蛋白质组学、基因组蛋白质等研究将对血小板的生物学功能研究产生重大的影响,且血小板蛋白质组学已被应用于解析血小板蛋白质组的各种复杂生物过程。本文对血小板蛋白质组学研究的最新进展作一综述,诸如蛋白质组学及其相关研究技术,与血小板相关的蛋白质组学及血小板蛋白质组学和疾病等。

Research progress of platelet proteomics - review

Human blood platelets play an important role in a variety of basic life processes, and are widely involved in various biological processes in the human body, including inflammation, wound healing and thrombosis etc. As unnuclear cell particles, platelets do not lend themselves to analysis by traditional cell and molecular biology techniques. In contrast, the study of proteomics and the protein complement of a genome will have a major impact on platelet biology. Moreover, platelet proteomics has been used to analyze a variety of complex biological processes in platelet proteome. This article will review the latest progress on platelet proteomics research, such as the proteomics and its related techniques, proteomics associated with platelets (static and activated platelet protemics, platelet microparticle proteomics, platelet membrane proteomics, platelet phospholation proteomics) as well as platelet proteomics and diseases.