他达那非不同给药方法治疗勃起功能障碍的疗效观察

目的:评估他达那非按需给药和每日给药1次治疗勃起功能障碍(ED)的疗效。方法:随机将ED男性分为按需给药组、每天5 mg他达那非组及每天10 mg他达那非组,治疗周期42 d,应用"性活动日志"来评估疗效,同时监测药物不良反应及重要迹象来评估药物安全性。结果:共53例患者完成研究,3组均对ED有较好的疗效,能显著提高性交成功率,并且药物的不良反应相当,均可以耐受。每日给药1次组SEP的5个问题阳性结果与按需给药组类似。结论:每日给药1次与按需给药在增加患者的勃起次数以及性体验满意度方面没有差异。

Effects of tadalafil on erectile dysfunction: on-demand versus once-daily dosing

Objective: To evaluate the effects of tadalafil administered on demand or once a day in the treatment of erectile dysfunction(ED).Methods: We randomly assigned 61 ED patients to three groups to receive tadalafil on demand,at 5 mg once daily,and at 10 mg once daily,respectively.After 42 days of medication,we compared the therapeutic effects among different groups using the patients’ sexual encounter profile(SEP) diaries,detected the adverse reactions and assessed the safety of tadalafil.Results: Fifty-three(86.7%) of the patients completed the investigation,and all responded well to tadalafil medication,with a significantly improved success rate of sexual intercourse and a low rate of mild adverse effects.The mean positive rates of SEP were basically similar between the on-demand and once-daily groups.Conclusion: There are no significant differences in the improvement of penile erection and sexual satisfaction of ED patients treated by on-demand and once-daily administration of tadalafil.