Synthesis and biological activity of substituted 7-aza-8-aza(oxa)-bicyclo[4.3.0]-6,9-nonadienes |
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| Authors: | N O Smirnova O P Plotnikov N A Vinogradova V V Sorokin A P Kriven'ko |
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| Institution: | (1) Russian Antiplague Research Institute  Mikrob , Saratov University, Saratov, Russia |
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| Abstract: | Hydroxylamine- and hydrazine-induced heterocyclization of readily available 5-hydroxy-2.4-diacetyl-5-methyl-3R-cyclohexanones (R = methyl, phenyl, m-nitrophenyl,  -furyl) yielded 6-acetyl-5-hydroxy-5.9-dimethyl-7R-1-aza(oxa)-2-azabicyclo4.3.0]-2,8-nonadienes (R = methyl, phenyl,m-nitrophenyl. -furyl). The biological activity of the latter was tested using theEscherichia coli phage T4, and was also tested on a stored lyophilized culture ofYersinia pestis EU. |
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