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Eupartoium makinoi suppresses lipopolysaccharide-induced inducible nitric oxide synthase and cyclooxygenase-2 expression |
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| Authors: | Sang-Il Ahn Se Jin Lim Gyo-Jeong Gu Ji-Soo Kim Ji Hun Paek Songmun Kim |
| Affiliation: | 1. Departments of Medical Science, College of Medical Sciences, SoonChunHyang University, Chungnam, Asan 336-745, Republic of Korea;2. Department of Biomedical Laboratory Science, College of Medical Sciences, SoonChunHyang University, Chungnam, Asan 336-745, Republic of Korea;3. Department of Food Science and Nutrition, Hallym University, Chuncheon, Gangwon 200-702, Republic of Korea;4. Department of Biological Environment, Kangwon National University, Chuncheon, Gangwon-do 200-701, Korea |
| Abstract: | Inflammation is involved in numerous diseases including cancer. Inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) play important roles in the development of certain inflammatory diseases. Eupatorium makinoi, which belongs to a family of Asteraceae plants, is used medicinally in East Asia. We investigated the effects of an ethanol extract of E. makinoi (EEM) on nuclear factor-kappa B (NF-κB) activation and the expression of iNOS and COX-2 with lipopolysaccharide (TLR4 agonist) in murine macrophages. EEM suppressed NF-κB activation and iNOS and COX-2 expression induced by LPS. These results suggest that EEM may regulate TLR4 signalling pathways and this may be a useful strategy for anti-inflammatory therapies. |
| Keywords: | Eupatorium makinoi lipopolysaccharide nuclear factor-κB cyclooxygenase-2 inducible nitric oxide synthase |