Variability of bronchial measurements obtained by sequential CT using two computer-based methods |
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Authors: | Pierre-Yves Brillet Catalin I. Fetita André Capderou Mihai Mitrea Serge Dreuil Jean-Marc Simon Françoise Prêteux Philippe A. Grenier |
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Affiliation: | 1. Université Paris XIII, UPRES EA 2363, Bobigny, France 2. Service de Radiologie, Assistance Publique–H?pitaux de Paris, H?pital Avicenne, Bobigny, France 8. Service de Radiologie, H?pital Avicenne, 125, rue de Stalingrad, 93009, Bobigny Cedex, France 3. ARTEMIS Department, TELECOM & Management SudParis, Evry, France 4. Laboratoire de Physiologie CCML, Le Plessis-Robinson, Université Paris XI, UPRES EA2397, Paris, France 5. Service de Radiothérapie Oncologique, Assistance Publique–H?pitaux de Paris, H?pital Pitié–Salpêtrière, Paris, France 6. Service de Radiologie, Assistance Publique–H?pitaux de Paris, H?pital Pitié–Salpêtrière, Paris, France 7. Institut National de la Santé et de la Recherche médicale U678, Université Pierre et Marie Curie–Paris VI, Paris, France
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Abstract: | This study aimed to evaluate the variability of lumen (LA) and wall area (WA) measurements obtained on two successive MDCT acquisitions using energy-driven contour estimation (EDCE) and full width at half maximum (FWHM) approaches. Both methods were applied to a database of segmental and subsegmental bronchi with LA > 4 mm2 containing 42 bronchial segments of 10 successive slices that best matched on each acquisition. For both methods, the 95% confidence interval between repeated MDCT was between –1.59 and 1.5 mm2 for LA, and –3.31 and 2.96 mm2 for WA. The values of the coefficient of measurement variation (CV10, i.e., percentage ratio of the standard deviation obtained from the 10 successive slices to their mean value) were strongly correlated between repeated MDCT data acquisitions (r > 0.72; p < 0.0001). Compared with FWHM, LA values obtained using EDCE were higher for LA < 15 mm2, whereas WA values were lower for bronchi with WA < 13 mm2; no systematic EDCE underestimation or overestimation was observed for thicker-walled bronchi. In conclusion, variability between CT examinations and assessment techniques may impair measurements. Therefore, new parameters such as CV10 need to be investigated to study bronchial remodeling. Finally, EDCE and FWHM are not interchangeable in longitudinal studies. |
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Keywords: | Computer-aided diagnosis Asthma Chronic obstructive pulmonary disease Multidetector-row CT Software validation |
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