| 盐酸青藤碱肠溶缓释微丸的制备 |
| |
| 引用本文： | 连燕飞,郑春丽,朱家壁,刘建平.盐酸青藤碱肠溶缓释微丸的制备[J].药学与临床研究,2013,21(3):218-220. |
| |
| 作者姓名： | 连燕飞 郑春丽 朱家壁 刘建平 |
| |
| 作者单位： | 连燕飞 (中国药科大学药物制剂研究所,南京,210009)； 郑春丽 (中国药科大学药物制剂研究所,南京,210009)； 朱家壁 (中国药科大学药物制剂研究所,南京,210009)； 刘建平 (中国药科大学药物制剂研究所,南京,210009)； |
| |
| 摘 要： | 目的：制备盐酸青藤碱肠溶缓释微丸。方法：分别以Eudragit NE30D为缓释膜材，HPMC E5为隔离层膜材，Eudragit L30D-55为肠溶层膜材，采用流化床包衣法制备盐酸青藤碱肠溶缓释微丸，并考察缓释层、隔离层和肠溶层包衣增重对药物释放的影响。结果：制备的肠溶缓释微丸在人工胃液中释放度<10%，人工肠液中缓慢释放8 h。结论：该制备工艺简单易行，重现性好，有望应用于工业化生产。
|
| 关 键 词： | 盐酸青藤碱 肠溶缓释微丸 流化床 |
| 收稿时间： | 2013/2/28 0:00:00 |
| 修稿时间： | 2013/3/16 0:00:00 |
Preparation of Sinomenine Hydrochloride Enteric-coated and Sustained-release Pellets |
| |
| LIAN Yan-fei,ZHENG Chun-li,ZHU Jia-bi and LIU Jian-ping.Preparation of Sinomenine Hydrochloride Enteric-coated and Sustained-release Pellets[J].Pharmacertical and Clinical Research,2013,21(3):218-220. |
| |
| Authors: | LIAN Yan-fei ZHENG Chun-li ZHU Jia-bi and LIU Jian-ping |
| |
| Institution: | Pharmaceutical Research Institution, China Pharmaceutical University, Nanjing 210009, China;Pharmaceutical Research Institution, China Pharmaceutical University, Nanjing 210009, China;Pharmaceutical Research Institution, China Pharmaceutical University, Nanjing 210009, China;Pharmaceutical Research Institution, China Pharmaceutical University, Nanjing 210009, China |
| |
| Abstract: | Objective: To develop the sinomenine hydrochloride enteric-coated and sustained-release pellets. Methods: Sinomenine hydrochloride enteric-coated and sustained-release pellets were prepared with Eudragit NE30D, HPMC E5 and Eudragit L30D-55 coating by fluid-bed, then the dissolutions were detected at different coating levels. Results: The accumulative release of the prepared pellets in the artificial gastric juice after 2 hours was lower than 10% and dissolved slowly in artificial intestinal liquid in 8 hours. Conclusion: This preparation processing is simple and feasible with good reproducibility. And it may be used in industrial production. |
| |
| Keywords: | Sinomenine hydrochloride Enteric-coated and sustained-release pellets Fluid-bed |
|
| 点击此处可从《药学与临床研究》浏览原始摘要信息 |
| 点击此处可从《药学与临床研究》下载免费的PDF全文 |
|
