HLA-A*01-restricted cytotoxic T-lymphocyte epitope from the Plasmodium falciparum circumsporozoite protein |
| |
Authors: | Kumar A Kumar S Le T P Southwood S Sidney J Cohen J Sette A Hoffman S L |
| |
Affiliation: | Malaria Program, Naval Medical Research Center, Silver Spring, Maryland 20910-7500, USA. kumara@nmrc.navy.mil |
| |
Abstract: | Here, we report the identification of a novel CD8+ cytotoxic T-lymphocyte epitope on the Plasmodium falciparum circumsporozoite protein (3D7; amino acids 310 to 319 [EPSDKHIKEY]) that is restricted by HLA-A*01 and is recognized by human volunteers immunized with irradiated P. falciparum sporozoites. HLA-A*01 is the second most common HLA allele among Caucasians. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|