Emerging roles for Interleukin-11 in disease |
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| Authors: | Paul M. Nguyen Suad M. Abdirahman |
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| Affiliation: | 1. The Walter and Eliza Hall Institute of Medical Research, Victoria, Australia;2. The Department of Medical Biology, The University of Melbourne, Victoria, Australia |
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| Abstract: | Interleukin (IL)-11 belongs to the IL-6 family of cytokines, discovered over 30 years ago. While early studies focused on the ability of IL-11 to stimulate megakaryocytopoiesis, the importance of this cytokine to inflammatory disease and cancers is only just beginning to be uncovered. This review outlines recent advances in our understanding of IL-11 biology, and highlights the development of novel therapeutics with the potential for clinical targeting of signaling by this cytokine in multiple diseases. |
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| Keywords: | Interleukin STAT3 signaling |
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