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Orbital Inflammatory Syndrome and Anterior Uveitis: A Case Series
Authors:Eric L. Crowell  Alden K. Bahr  Ore-ofe O. Adesina  Ankur A. Kamdar  Kartik S. Kumar
Affiliation:1. Ruiz Department of Ophthalmology and Visual Science, McGovern Medical School at The University of Texas Health Science Center at Houston (UTHealth), Houston, Texas, USA;2. Robert Cizik Eye Clinic, Houston, Texas, USA;3. Memorial Hermann Hospital, Texas Medical Center, Houston, Texas, USA;4. Department of Neurology, McGovern Medical School at UTHealth, Houston, Texas, USA;5. Department of Pediatrics, McGovern Medical School at UTHealth, Houston, Texas, USA
Abstract:Purpose: To describe four cases of orbital inflammatory syndrome (OIS) with associated anterior uveitis that have presented within 2 years to our practice.

Methods: Charts of patients diagnosed with OIS from June 2013 to May 2015 were reviewed.

Results: Four patients, three children and one adult, presented with orbital swelling, pain, and varying degrees of vision loss. Treatment with intravenous methylprednisolone resulted in significant symptomatic improvement in all cases initially; when symptoms recurred, the patients had evidence of anterior uveitis. With continued systemic therapy and the addition of topical prednisolone, the patients all achieved control of their uveitis and OIS and are well controlled with regular outpatient follow-up.

Conclusions: Reports of OIS-associated with uveitis are relatively rare. The presentation of three pediatric patients and one adult patient to the same practice with OIS and secondary uveitis within a 2-year period may indicate that the association is underreported.
Keywords:Anterior uveitis  idiopathic orbital inflammation  inflammatory orbital pseudotumor  nonspecific orbital inflammation  orbital inflammatory syndrome
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