注射用益气复脉（冻干）治疗慢性心力衰竭伴低血压的临床研究

目的 观察注射用益气复脉（冻干）治疗慢性心力衰竭伴低血压的疗效。方法 选取郑州市中医院2018年10月-2020年2月心内一科收治的120例慢性心力衰竭并低血压患者，采用随机数字法分为对照组（53例）和观察组（55例）。对照组针对原发病进行一般治疗。观察组在对照组治疗的基础上给予注射用益气复脉（冻干），2.6~5.2 g加入5%葡萄糖注射液或0.9%氯化钠注射液250~500 mL中静滴，1次/d，连续使用7~14 d。观察两组患者的临床疗效，同时比较两组患者治疗前后的左室射血分数（LVEF）、N端脑钠肽前体（NT-proBNP）、心率、生活质量评分和血压水平。结果 治疗后，观察组患者总有效率为96.4%，显著高于对照组的84.9%，两组比较差异有统计学意义（P<0.05）。治疗后，两组LVEF显著升高，NT-proBNP、心率和生活质量评分均明显降低，同组治疗前后比较差异有统计学意义（P<0.05）；观察组在NTproBNP水平和生活质量评分显著低于于对照组（P<0.05）。治疗后，两组血压均有明显升高，同组治疗前后比较差异有统计学意义（P<0.05），治疗后，观察组的血压水平显著高于对照组，两组比较差异有统计学意义（P<0.05）。结论 注射用益气复脉（冻干）治疗慢性心力衰竭合并低血压不仅能有效改善患者的心功能，减轻临床症状，而且能进一步提升低血压患者的血压水平。

Clinical study on Yiqi Fumai Lyophilized Injection in treatment of chronic heart failure with hypotension

Objective To observe the curative effect of Yiqi Fumai Lyophilized Injection in treatment of chronic heart failure with hypotension. Methods 120 cases of patients with chronic heart failure and hypotension in the Zhengzhou Municipal Hospital of TCM from October 2018 to February 2020 were randomly divided into control group (53 cases) and observation group (55 cases). Patients in the control group received general treatment for the primary disease. Patients in the observation group were injected with Yiqi Fumai Lyophilized Injection on the basis of control group, 2.6 g-5.2 g added with 5% glucose injection or 0.9% sodium chloride injection for 250-500 mL, once daily, and patients were continuously treated for 7-14 d. After treatment, the clinical efficacy in two groups were observed, and the LVEF, NT-proBNP, heart rate, quality of life score, and blood pressure level in two groups before and after treatment were compared. Results After treatment, the total effective rate in the observation group was 96.4%, which was significantly higher than 84.9% in the control group, and the difference between two groups was statistically significant (P<0.05). After treatment, LVEF in two groups was significantly increased, but NT-proBNP, heart rate, and quality of life scores were significantly reduced, and the differences before and after treatment in the same group were statistically significant (P<0.05). And the NT-proBNP level and quality of life score in the observation group were significantly lower than those in the control group (P<0.05). After treatment, the blood pressure in two groups were increased significantly, and the difference in the same group before and after treatment was statistically significant (P<0.05). After treatment, the blood pressure level in the observation group was significantly higher than that in the control group, and the difference between two groups was statistically significant (P<0.05). Conclusion Yiqi Fumai Lyophilized Injection in treatment of chronic heart failure with hypotension can not only effectively improve the cardiac function of patients, reduce clinical symptoms, but also further improve the blood pressure level of patients with hypotension.