The effect of leukocyte-platelet-rich fibrin on bone morphogenetic protein-2 and insulin-like growth factor-1 levels in patients with chronic periodontitis: a randomized split mouth clinical trail |
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| Authors: | Alper Kizildağ Yasin Çiçek Taner Arabaci Oğuz Köse |
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| Affiliation: | 1. Department of Periodontology, Faculty of Dentistry, Pamukkale University, Denizli, Turkey;2. alperkizildag@hotmail.com;4. Department of Periodontology, Faculty of Dentistry, Ad?yaman University, Ad?yaman, Turkey;5. Department of Periodontology, Faculty of Dentistry, Atatürk University, Erzurum, Turkey;6. Department of Periodontology, Faculty of Dentistry, Recep Tayyip Erdogan University, Rize, Turkey |
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| Abstract: | The present study evaluates the effects of leukocyte-platelet-rich fibrin (L-PRF) combined with open flap debridement (OFD) on clinical parameters and growth factors levels (GFL) in chronic periodontitis (CP) patients. This trial was registered at clinicaltrials.gov as NCT02594605. 16 patients (32 sites) with chronic periodontitis who had at least two areas of horizontal bone loss, were treated with OFD alone or L-PRF with OFD (OFD?+?L-PRF). GFL in gingival crevicular fluid (GCF) were analyzed at baseline, 1?week, 2?weeks and 4?weeks after operation. Probing depth (PD) and clinical attachment level (CAL) were measured at baseline and 6?months postoperatively. PD reduction and CAL gain were significantly higher in the OFD?+?L-PRF sites than in OFD sites. OFD?+?L-PRF group showed significantly increased bone morphogenetic protein-2 and insulin-like growth factor-1 at 2?weeks compared with baseline. L-PRF combined with OFD significantly increases GFL and thus, it enhances the periodontal healing on CP patients. |
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| Keywords: | Periodontitis BMP-2 IGF-1 wound healing |
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