肿瘤细胞免疫原性死亡研究进展

某些化疗药物在诱导肿瘤细胞发生凋亡的同时还能诱导肿瘤细胞产生免疫原性死亡，通常具有更好的治疗效果。该过程主要为发生凋亡的肿瘤细胞上调某些特征蛋白（如钙网蛋白、高迁移率族蛋白B1）在细胞表面表达，从而诱导未成熟的树突细胞发育为成熟的树突细胞，并将肿瘤抗原提呈给细胞毒性T细胞，最终激活肿瘤特异性毒性T细胞杀伤肿瘤细胞，达到更好的治疗效果。对肿瘤免疫原性死亡的研究将为肿瘤治疗提供新的方法和手段，为肿瘤免疫研究提供新思路。

Progress in immunogenic cancer cell death

Certain chemotherapeutic drugs can induce tumor cells apopotosis and can also elicit immunogenic cell death (ICD). Chemotherapeutic drugs that elicit immunogenic cell death generally have great therapeutic effects. This process is mainly characterized by up-regulation of certain characteristic protein molecules, such as calreticulin (CRT), on the surface of apoptotic cells. These proteins can induce immature dendritic cells to become maturation and present tumor antigens to cytotoxic T cells. Eventually, ICD can activate tumor-specific cytotoxic T cells to kill tumor cells and ultimately achieve a better therapeutic effects. The study of tumor ICD will provide new methods and approaches for tumor treatment and provide new ideas for tumor immunity study.