Effect of metformin on the clinical and metabolic assessment of women with polycystic ovary syndrome |
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| Authors: | L Ferreira Santana MF Silva de Sá RA Ferriani MD de Moura MC Foss RM dos Reis |
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| Affiliation: | 1. Sector of Human Reproduction, Department of Gynecology and Obstetrics, University of S?o Paulo, Ribeir?o Preto, Brazil;2. Department of Internal Medicine, Faculty of Medicine of Ribeir?o Preto, University of S?o Paulo, Ribeir?o Preto, Brazil |
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| Abstract: | A longitudinal prospective study was conducted in 21 women with polycistic ovary syndrome (PCOS), aged 27.20?±?5.02 years and treated with metformin (1500?mg/day) for 8 weeks. The patients were assessed for spontaneous menstruation, weight, body mass index (BMI), waist circumference, waist/hip ratio (WHR), glucose and insulin concentrations under fasting conditions and after a 75-g glucose tolerance test, lipid profile, testosterone, androstenedione, dehydroepiandrosterone sulfate, sex-hormone binding globulin (SHBG), and insulin-like growth factor (IGF)-I. Spontaneous menstruation was observed in 81% of the women treated with metformin, with no changes in weight or BMI. Waist measurement and the WHR were reduced. The quantitative insulin sensitivity check index (QUICKI) improved from 0.33?±?0.03 to 0.35?±?0.04 (p? |
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| Keywords: | Metformin Insulin Resistance Polycystic Ovary Syndrome PCOS Chronic Anovulation Hyperandrogenism |
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