Contribution of pancreatic enzyme replacement therapy to survival and quality of life in patients with pancreatic exocrine insufficiency |
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Authors: | Peter Layer Nataliya Kashirskaya Natalya Gubergrits |
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Institution: | Peter Layer, Department of Internal Medicine, Israelitic Hospital, Hamburg 22297, GermanyNataliya Kashirskaya, Department of Genetic Epidemiology (Cystic Fibrosis group), Federal State Budgetary Institution “Research Centre for Medical Genetics”, Moscow 115522, RussiaNatalya Gubergrits, Department of Internal Medicine, Donetsk National Medical University, Lyman 83001, Ukraine |
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Abstract: | The objective of this study was to analyze the current evidence for the use of pancreatic enzyme replacement therapy(PERT) in affecting survival and quality of life in patients with pancreatic exocrine insufficiency(PEI). Systematic searches of the literature were performed using the PubMed database. Articles were selected for inclusion if they reported findings from trials assessing the effects of PERT on quality of life, survival, malabsorption, growth parameters(such as height, body weight and body mass index), or gastrointestinal symptoms(such as abdominal pain, stool consistency and flatulence). PERT improved PEI-related malabsorption and weight maintenance in patients with cystic fibrosis, chronic pancreatitis, pancreatic cancer, and post-surgical states. In patients with chronic pancreatitis, PERT improved PEI-related symptoms and quality of life measures.Several small retrospective studies have also suggested that PERT may have a positive impact on survival, but long-term studies assessing this effect were not identified. PERT is effective for treating malnutrition and supporting weight maintenance, and it is associated with improved quality of life and possibly with enhanced survival in patients with PEI. However, there is evidence that not all patients with PEI receive adequate PERT. Future work should aim to assess the long-term effects of PERT on the survival of patients with PEI. |
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Keywords: | Pancreatic exocrine insufficiency Pancreatic enzyme replacement therapy Survival Quality of life Malabsorption Cystic fibrosis Chronic pancreatitis Pancreatic cancer Post-surgical states |
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