Relationship of fibroblast growth factor 21, sirtuin 1, visfatin,and regulators in children with short stature |
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| Authors: | Davut Sinan Kaplan Emregul Isık Mustafa Orkmez Burcu Kumru |
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| Affiliation: | 1. Medical Faculty, Department of Physiology, Health Sciences Institution, University of Gaziantep, Gaziantep, Turkey;2. The Polyclinic Child Endocrinology, Gaziantep Cengiz G?kcek Maternity and Children’s Hospital, Gaziantep, Turkey;3. Medical Faculty, Department of Medical Biochemistry, Health Sciences Institution, University of Gaziantep, Gaziantep, Turkey;4. Nutritionist, Division of Nutrition and Diet, Gaziantep Cengiz G?kcek Maternity and Children’s Hospital, Gaziantep, Turkey |
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| Abstract: | Fibroblast growth factor 21 (FGF21) is mainly secreted by the liver. It is a factor that is not fully understood in relation to growth. Sirtuin 1 (SIRT1) is a deacetylase protein. It is thought that may have an effect on the release and function of GH and IGF-1. Visfatin is synthesized from adipose tissue as primary. It may be prognostic marker associated with growth factors. As a result of our work, FGF21 is not associated with short stature but levels of SIRT1 and visfatin are associated with short stature. The decrease in visfatin value in the short-stature group is thought to be due to an insufficient amount of adipose tissue, which is important for growth and development. SIRT1 might decrease GH effect by increasing STAT5 deacetylation in the liver and we think that the result of this reduction of SIRT1 would negatively impact IGF-1 and IGFBP-3 production. |
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| Keywords: | FGF21 IGF-1 IGFBP-3 SIRT1 visfatin |
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