Association Study of ARMC9 Gene Variants with Vogt-Koyanagi-Harada Disease in Japanese Patients |
| |
| Authors: | Tomoko Ohno Masaki Takeuchi Takahiro Yamane Takeshi Teshigawara Nobuyoshi Kitaichi |
| |
| Affiliation: | 1. Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa, Japan;2. Yokosuka Chuoh Eye Clinic, Yokohama, Kanagawa, Japan;3. Tsurumi Chuoh Eye Clinic, Yokohama, Kanagawa, Japan;4. Department of Ophthalmology, Health Sciences University of Hokkaido, Sapporo, Hokkaido, Japan;5. Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan |
| |
| Abstract: | Purpose: To investigate whether variants in the ARMC9 gene encoding KU-MEL-1 are associated with Vogt-Koyanagi-Harada (VKH) disease in a Japanese population.Methods: We recruited 380 Japanese patients with VKH disease and 744 Japanese healthy controls to genotype seven single-nucleotide polymorphisms (SNPs) in ARMC9. We also performed imputation analysis of the ARMC9 region and 195 imputed SNPs were included in the statistical analysis.Results: We observed an increased frequency of the A allele of rs28690417 in patients compared with controls (P = 0.0097, odds ratio (OR) = 1.46). The A allele had a dominant effect on VKH disease risk (P = 0.011, OR = 1.51). However, these significant differences disappeared after Bonferroni correction (corrected P > 0.05). The remaining 201 SNPs did not show any significant association with disease risk.Conclusions: Our study suggests that ARMC9 variants do not play a critical role in the development of VKH disease. |
| |
| Keywords: | ARMC9 association study single nucleotide polymorphism susceptibility gene Vogt-Koyanagi-Harada disease |
|
|
