Platelet function and lipid-lowering interventions |
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| Authors: | Haralampos J. Milionis Moses S. Elisaf Dimitri P. Mikhailidis |
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| Affiliation: | 1. Department of Molecular Pathology and Clinical Biochemistry, Royal Free and University College Medical School, University College, Royal Free Campus (University of London), London, UK;2. Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece |
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| Abstract: | Platelets play an important role in the process of atherothrombosis, and antiplatelet therapy is of proven efficacy in the prevention of vascular events in high-risk patients. In this review, we briefly consider the studies reporting that circulating atherogenic lipoproteins enhance platelet activity. We also evaluate the evidence showing that lipid-lowering interventions (including the use of statins) are associated with the normalisation of platelet activity. This beneficial effect should enhance the anti-atherogenic and anti-thrombotic potential of lipid-lowering interventions. |
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